产品货号：
GS4492
中文名称：
重组人NT-4
英文名称：
Recombinant Human Neurotrophin-4
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 28.1kDa,a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers(262 total amino acid residues).
储存条件：冷冻（-20℃）
概述
NT-4 also named as NT-5 is a neuronal and epithelial grow factor belongs to the NGF-beta family.The NT-4 precursor is consisted of a 24 a.a.signal peptide,a 56 a.a.propertied and 130 a.a.NT-4.The mature protein has six Cys amino acid residues and has the relative structure with NT-3,BDNF(sharing about 48%- 52%sequence identity).Additionally,it shares 91%and 95%a.a.sequence identity with mouse and rat NT-4.NT-4 is mainly expressed in prostate and has low level thymus,placenta,and skeletal muscle.It can binding with the LNGFR and trkB receptors and plays a crucial role in the regulation of survival and the maintenance of peripheral sensory sympathetic neurons.Defect of NT-4 may cause primary open angle glaucoma type 1O.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人NT-4，NT-4, Human，Recombinant Human Neurotrophin-4
储存条件：冷冻（-20℃）
概述
NT-4 also named as NT-5 is a neuronal and epithelial grow factor belongs to the NGF-beta family.The NT-4 precursor is consisted of a 24 a.a.signal peptide,a 56 a.a.propertied and 130 a.a.NT-4.The mature protein has six Cys amino acid residues and has the relative structure with NT-3,BDNF(sharing about 48%- 52%sequence identity).Additionally,it shares 91%and 95%a.a.sequence identity with mouse and rat NT-4.NT-4 is mainly expressed in prostate and has low level thymus,placenta,and skeletal muscle.It can binding with the LNGFR and trkB receptors and plays a crucial role in the regulation of survival and the maintenance of peripheral sensory sympathetic neurons.Defect of NT-4 may cause primary open angle glaucoma type 1O.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures is less than 50ng/ml,corresponding to a specific activity of>2.0×104 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 5.5. |
| 内毒素 | Less than 1 EU/μg of rHuNT-4 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A |
相关搜索：重组人NT-4，NT-4, Human，Recombinant Human Neurotrophin-4